反应详情

A 500 mL side arm flask equipped with a thermometer and an addition funnel with a nitrogen inlet was charged with 100 mL of toluene and 2.00 g (0.10 mol) of 50% hydroxylamine in water. A solution of 4.41 g of 2,6-dimethylphenyl isocyanate (0.03 mol) dissolved in 50 mL of toluene was added dropwise over 15 min. External cooling was used to maintain the, internal reaction temperature below 25° C. Stirring was continued at room temp for 18 h. The solvent was removed under reduced pressure to give a white solid. The residual solvent was further co-evaporated twice with toluene, then oven dried overnight to give the desired product (5.25 g) as a white solid melting at 192-193° C.

1. customA 500 mL side arm flask equipped with a thermometer and an addition funnel with a nitrogen inlet
2. additionwas added dropwise over 15 min
3. temperatureExternal cooling
4. temperatureto maintain the, internal reaction temperature below 25° C
5. customThe solvent was removed under reduced pressure
6. customto give a white solid
7. customoven dried overnight