Benzylamine → HCID 1244709, compound

HRID 1582581Notes

Reaction equation

HRID 1582581 reaction equation
[C:1]1([S:7]([CH:10]([NH:15][C:16]([C:18]2[S:19][CH:20]=[CH:21][CH:22]=2)=[O:17])[C:11](Cl)(Cl)Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:23]([NH2:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O1CCCC1>[C:1]1([S:7]([C:10]2[N:15]=[C:16]([C:18]3[S:19][CH:20]=[CH:21][CH:22]=3)[O:17][C:11]=2[NH:30][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 22718384HCID 22718384, compound

Product 1

HCID 1244709HCID 1244709, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

N(1-Phenylsulfonyl-2,2,2-trichloroethyl)thiophene-2-carboxamide (0.4 g, 1.003 mmol) is dissolved in tetrahydrofuran, mixed with benzylamine (0.428 g, 4.012 mmol) and stirred overnight at room temperature. The resulting precipitate was filtered off with suction and discarded, the mother liquor was concentrated in a rotary evaporator and the residue was crystallized in 15 ml of petroleum ether, filtered off with suction and dried in air.

Workup

  1. filtrationThe resulting precipitate was filtered off with suction
  2. concentrationthe mother liquor was concentrated in a rotary evaporator
  3. customthe residue was crystallized in 15 ml of petroleum ether
  4. filtrationfiltered off with suction
  5. customdried in air

Sources & evidence

ORD record
ord-e1ca826a198d43718f49aa0a539d7644
Source dataset
uspto-grants-2004_05
Patent number
US06737426B1

Reaction notes

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