Benzhydrylamine → HCID 178527041, compound

HRID 1582590Notes

Reaction equation

HRID 1582590 reaction equation
[C:1]1([CH:7]([NH2:14])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:15]1(=O)[CH2:19][CH2:18][CH2:17][CH2:16]1.O1CCCC1.[PH2:26](=[O:28])[OH:27]>O>[C:1]1([CH:7]([NH:14][C:15]2([PH:26](=[O:27])[OH:28])[CH2:19][CH2:18][CH2:17][CH2:16]2)[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 7036BenzhydrylamineHCID 8028TetrahydrofuranHCID 8452CyclopentanoneHCID 4124402Phosphinic Acid

Product 1

HCID 178527041HCID 178527041, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Diphenylmethylamine (4.00 ml) and cyclopentanone (2.06 ml) were stirred at 120° C. for 3 hours, and then the mixture was returned to room temperature and added with tetrahydrofuran (2 ml) and phosphinic acid (1.8 g). The mixture was stirred at room temperature for 3 minutes, and then allowed to stand for 17 hours. Water (20 ml) was added to the reaction system, and the insoluble solid was collected by filtration and washed with tetrahydrofuran, and then dried to obtain crude 1-(diphenylmethylamino)cyclopentylphosphinic acid (1.53 g). This compound was subjected to the measurement of molecular weight and then used in the following reaction.

Workup

  1. customwas returned to room temperature
  2. waitto stand for 17 hours
  3. filtrationthe insoluble solid was collected by filtration
  4. washwashed with tetrahydrofuran
  5. customdried

Sources & evidence

ORD record
ord-d5a192b66c144033a642fb164499ac9d
Source dataset
uspto-grants-2004_05
Patent number
US06737416B2

Reaction notes

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