2,4-Dichlorobenzyl chloride → 2-(5-chloro-2-((2,4-dichlorobenzyl)oxy)phenyl)-1-(1H-1-imidazolyl)-2-propanol

HRID 1582622Notes

Reaction equation

HRID 1582622 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]([OH:17])([CH3:16])[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:3]=1.[Cl:18][C:19]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:20]=1[CH2:21]Cl>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:21][C:20]2[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:19]=2[Cl:18])=[C:4]([C:9]([OH:17])([CH3:16])[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:3]=1

Participants

3

Reactant 2

HCID 72122,4-Dichlorobenzyl chlorideHCID 129728974-chloro-2-(1-hydroxy-2-(1H-1-imidazolyl)-1-methylethyl)phenol2×

Product 1

HCID 129729022-(5-chloro-2-((2,4-dichlorobenzyl)oxy)phenyl)-1-(1H-1-imidazolyl)-2-propanolYield 51.9%

Procedure

The general procedure of Example 6 was repeated using 4-chloro-2-(1-hydroxy-2-(1H-1-imidazolyl)-1-methylethyl)phenol [compound (2-1)] and 2,4-dichlorobenzyl chloride, to thereby yield 2-(5-chloro-2-((2,4-dichlorobenzyl)oxy)phenyl)-1-(1H-1-imidazolyl)-2-propanol as colorless crystals (yield: 51.9%).

Sources & evidence

ORD record
ord-37956bfe11a14bc9b52d2a0b5d3d6048
Source dataset
uspto-grants-2004_05
Patent number
US06737434B2

Reaction notes

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