1-Chloro-2-phenylethane → 1-(5-chloro-2-(phenethyloxy)phenyl)-1-cyclopropyl-2-(1H-1-imidazolyl)-1-ethanol

HRID 1582623Notes

Reaction equation

HRID 1582623 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([C:9]([CH:17]2[CH2:19][CH2:18]2)([OH:16])[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:3]=1.[CH2:20](Cl)[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[C:4]([C:9]([CH:17]2[CH2:19][CH2:18]2)([OH:16])[CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:3]=1

Participants

3

Reactant 2

HCID 2314961-Chloro-2-phenylethaneHCID 129728994-chloro-2-(1-cyclopropyl-1-hydroxy-2-(1H-1-imidazolyl)ethyl)phenol2×

Product 1

HCID 129729071-(5-chloro-2-(phenethyloxy)phenyl)-1-cyclopropyl-2-(1H-1-imidazolyl)-1-ethanolYield 26.4%

Procedure

The general procedure of Example 6 was repeated using 4-chloro-2-(1-cyclopropyl-1-hydroxy-2-(1H-1-imidazolyl)ethyl)phenol [compound (2-3)] and phenethyl chloride, to thereby yield 1-(5-chloro-2-(phenethyloxy)phenyl)-1-cyclopropyl-2-(1H-1-imidazolyl)-1-ethanol as colorless crystals (yield: 26.4%).

Sources & evidence

ORD record
ord-b4289f35ac3e49239e7a3376ec00dc88
Source dataset
uspto-grants-2004_05
Patent number
US06737434B2

Reaction notes

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