Trifluoroacetic acid → HCID 69929667, compound

HRID 1582741Notes

Reaction equation

HRID 1582741 reaction equation
C(O[C:6](=O)[N:7]([C@H:9]([C:25](=[O:38])[NH:26][CH2:27][C:28]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:31][CH2:30][CH2:29]1)[CH2:10][C:11]1[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)C)(C)(C)C.[C:40]([OH:46])([C:42]([F:45])([F:44])[F:43])=[O:41]>C(Cl)Cl>[F:43][C:42]([F:45])([F:44])[C:40]([OH:46])=[O:41].[CH2:18]([O:17][C:14]1[CH:15]=[CH:16][C:11]([CH2:10][C@H:9]([NH:7][CH3:6])[C:25]([NH:26][CH2:27][C:28]2([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[CH2:29][CH2:30][CH2:31]2)=[O:38])=[CH:12][CH:13]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69927875HCID 69927875, compound

Product 1

HCID 69929667HCID 69929667, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-{2-(4-Benzyloxy-phenyl)-1-[(1-phenyl-cyclobutylmethyl)-carbamoyl]-ethyl}-methyl-carbamic acid tert-butyl ester (from Step 1; 1.07 g, 2.02 mmol) in methylene chloride (10 mL) was added TFA (2.5 mL). The solution was stirred at room temperature for 2 hours and then concentrated in vacuo. Coevaporisation with methylene chloride was carried out twice to give the desired product which was used without further purification.

Workup

  1. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-6400e92f43bb4cb3a24dfc812ceaf6e6
Source dataset
uspto-grants-2004_05
Patent number
US06737410B1

Reaction notes

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