1-Benzylpiperazine → HCID 771364, compound

HRID 1582751Notes

Reaction equation

HRID 1582751 reaction equation
[C:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([F:12])=[CH:8][CH:7]=1)(=[O:4])[CH:2]=[CH2:3].[CH2:13]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CO>[CH2:13]([N:20]1[CH2:25][CH2:24][N:23]([CH2:3][CH2:2][C:1]([NH:5][C:6]2[CH:7]=[CH:8][C:9]([F:12])=[CH:10][CH:11]=2)=[O:4])[CH2:22][CH2:21]1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 759941-BenzylpiperazineHCID 3250203N-(4-fluorophenyl)prop-2-enamide

Product 1

HCID 771364HCID 771364, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-Acryloyl-4-fluoroaniline (12.2 g) and 1-benzyl piperazine (19.7 g) were dissolved in methanol (150 ml), and the mixture was stirred overnight at room temperature. The reaction mixture was evaporated, and the residue was purified by Cromatorex NH silica gel column chromatography (hexane/ethyl acetate system) to give the title compound (25 g, 100%) as a colorless oil.

Workup

  1. customThe reaction mixture was evaporated
  2. customthe residue was purified by Cromatorex NH silica gel column chromatography (hexane/ethyl acetate system)

Sources & evidence

ORD record
ord-27feb12059b24dd081fb78a1e555cd5f
Source dataset
uspto-grants-2004_05
Patent number
US06737425B1

Reaction notes

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