HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzylpiperazine → HCID 771364, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | N-(4-fluorophenyl)prop-2-enamide | HCID 3250203 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 771364 | HCID 771364 | 100% |
Reaction Steps
N-Acryloyl-4-fluoroaniline (12.2 g) and 1-benzyl piperazine (19.7 g) were dissolved in methanol (150 ml), and the mixture was stirred overnight at room temperature. The reaction mixture was evaporated, and the residue was purified by Cromatorex NH silica gel column chromatography (hexane/ethyl acetate system) to give the title compound (25 g, 100%) as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06737425B1 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-27feb12059b24dd081fb78a1e555cd5f |
| Source note | uspto-grants-2004_05 |