反应详情

温度

90 °C

2-(2-Acetoxy-4-fluorophenoxy)ethanol 1.53 g was dissolved in a mixed solvent of tetrahydrofuran 10 ml and water 5 ml, then lithium hydroxide monohydride 294 mg was added thereto, and the mixture was stirred at 90° C. After stirred for 10 hours, the reaction mixture was cooled and partitioned by adding water and ethyl acetate. The organic layer was washed with water and then with brine, dried over magnesium sulfate anhydride and evaporated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate system), whereby the title compound (1.07 g, 80%) was obtained as a colorless oil.

1. stirringAfter stirred for 10 hours
2. temperaturethe reaction mixture was cooled
3. custompartitioned
4. additionby adding water and ethyl acetate
5. washThe organic layer was washed with water
6. dry with materialwith brine, dried over magnesium sulfate anhydride
7. customevaporated
8. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate system), whereby the title compound (1.07 g, 80%)
9. customwas obtained as a colorless oil