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In a 100 mL flask equipped with a reflux condenser were placed 2.26 g of 5-nitro-1-tetralone and 60 mL of ethanol. To the mixture was added a solution of hydroxylamine hydrochloride (1.82 g) in water (4.5 mL). The content of the flask was stirred with a stirring bar at reflux for 8 hours. After evaporating the solvent, the residue was purified by column chromatography (eluent: hexane/ethyl acetate=5/1)′ to give 2.2 g of 5-nitro-1-tetralone oxime.

1. customIn a 100 mL flask equipped with a reflux condenser
2. temperatureat reflux for 8 hours
3. customAfter evaporating the solvent
4. customthe residue was purified by column chromatography (eluent: hexane/ethyl acetate=5/1)′