HRID1582818

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCOC(=O)C(CCCCCCC=CC[C@@H]1Cc2cc(OC)ccc2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@H]12)CCCC(F)(F)C(F)(F)F

HCID86588527

未命名化合物

PRODUCTS

生成物

HCID86588528

未命名化合物

收率 97%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID178418390

未命名化合物

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Ethyl 11-[17β-hydroxy-3-methoxyestra-1,3,5(10)-trien-7α-yl]-2-(4,4,5,5,5-pentafluoropentyl)-9-undecenoate (970 mg, 1.48 mmol) was dissolved in ethyl acetate (30 ml), and 10% palladium carbon (300 mg) was added to the resulting solution followed by stirring for 4 hours at room temperature under hydrogen atmosphere. The reaction mixture was filtered and concentrated to give ethyl 11-[17β-hydroxy-3-methoxyestra-1,3,5(10)-trien-7α-yl]-2-(4,4,5,5,5-penta-fluoropentyl)undecanoate (946 mg, Yield 97%) as an oil.

WORKUP

后处理

filtrationThe reaction mixture was filtered
concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a302e3a57dc64786a46660fee179f4a1
来源数据集: uspto-grants-2004_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06737417B2
来源说明: uspto-grants-2004_05

反应 SMILES

[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:17]([CH2:18][CH2:19][C@:3]12[CH3:4])[C:16]1[CH:15]=[CH:14][C:13]([O:20][CH3:21])=[CH:12][C:11]=1[CH2:10][C@H:9]3[CH2:22][CH:23]=[CH:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH:31]([CH2:37][CH2:38][CH2:39][C:40]([F:46])([F:45])[C:41]([F:44])([F:43])[F:42])[C:32]([O:34][CH2:35][CH3:36])=[O:33]>C(OCC)(=O)C.[C].[Pd]>[OH:1][C@H:2]1[CH2:7][CH2:6][C@H:5]2[C@H:8]3[C@H:17]([CH2:18][CH2:19][C@:3]12[CH3:4])[C:16]1[CH:15]=[CH:14][C:13]([O:20][CH3:21])=[CH:12][C:11]=1[CH2:10][C@H:9]3[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH:31]([CH2:37][CH2:38][CH2:39][C:40]([F:45])([F:46])[C:41]([F:42])([F:43])[F:44])[C:32]([O:34][CH2:35][CH3:36])=[O:33]