Thionyl Chloride → 4-Amino-1-(2-chloroethyl)pyrimidin-2(1H)-one

HRID 1582934Notes

Reaction equation

HRID 1582934 reaction equation
O[CH2:2][CH2:3][N:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[N:6][C:5]1=[O:11].S(Cl)([Cl:14])=O>>[Cl:14][CH2:2][CH2:3][N:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[N:6][C:5]1=[O:11]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 367641HCID 367641, compound

Product 1

HCID 227156824-Amino-1-(2-chloroethyl)pyrimidin-2(1H)-one

Procedure

B] 1-(2-Chloroethyl)-4-amino-2-1H-pyrimidinone was prepared according to example 14C from 3.8 g 1-(2-hydroxyethyl)-4-amino-2-1H-pyrimidinone and 60 ml thionyl chloride. 3.2 g (97%) of crude product were obtained and used without further purification. Recrystallization was omitted in this case due to decomposition. Rf: 0.51 (ethyl acetate/acetone/acetic acid/H2O 6:2:1:1).

Sources & evidence

ORD record
ord-2c363cdce0a7492591780668dec645f1
Source dataset
uspto-grants-2004_05
Patent number
US06740642B2

Reaction notes

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