HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Amino-1-(2-chloroethyl)pyrimidin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 367641 | HCID 367641 | — |
| Product | 4-Amino-1-(2-chloroethyl)pyrimidin-2(1H)-one | HCID 22715682 | — |
Reaction Steps
B] 1-(2-Chloroethyl)-4-amino-2-1H-pyrimidinone was prepared according to example 14C from 3.8 g 1-(2-hydroxyethyl)-4-amino-2-1H-pyrimidinone and 60 ml thionyl chloride. 3.2 g (97%) of crude product were obtained and used without further purification. Recrystallization was omitted in this case due to decomposition. Rf: 0.51 (ethyl acetate/acetone/acetic acid/H2O 6:2:1:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06740642B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-2c363cdce0a7492591780668dec645f1 |
| Source note | uspto-grants-2004_05 |