Sodium Hydroxide → Rufinamide

HRID 1582946Notes

Reaction equation

HRID 1582946 reaction equation
[OH-:1].[Na+].[C:3]([C:5]1[N:6]=[N:7][N:8]([CH2:10][C:11]2[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=2[F:18])[CH:9]=1)#[N:4]>O>[F:17][C:16]1[CH:15]=[CH:14][CH:13]=[C:12]([F:18])[C:11]=1[CH2:10][N:8]1[CH:9]=[C:5]([C:3]([NH2:4])=[O:1])[N:6]=[N:7]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 110422394-Cyano-1-(2,6-difluorobenzyl)-1H-1,2,3-triazole

Product 1

HCID 129228Rufinamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
10 °C

Procedure

1 N sodium hydroxide solution (0.11 ml) is added to a mixture of 4-cyano-1-(2,6-difluorobenzyl)-1H-1,2,3-triazole (2.20 g) and water (44 ml) at an external temperature of 95-100° C. while stirring. After 90 minutes, the suspension is cooled to 10° C. and the product is isolated by filtration, washed with water and dried at about 60° C. in vacuo. 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide is obtained in this manner, yield: 99.2% by weight, Modification A.

Workup

  1. customthe product is isolated by filtration
  2. washwashed with water
  3. customdried at about 60° C. in vacuo

Sources & evidence

ORD record
ord-ee25f18ac60c4cf49d3ddad6c463c693
Source dataset
uspto-grants-2004_05
Patent number
US06740669B1

Reaction notes

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