Sodium Hydroxide → Rufinamide

Participants

Reaction Conditions

Reaction Steps

1 N sodium hydroxide solution (0.11 ml) is added to a mixture of 4-cyano-1-(2,6-difluorobenzyl)-1H-1,2,3-triazole (2.20 g) and water (44 ml) at an external temperature of 95-100° C. while stirring. After 90 minutes, the suspension is cooled to 10° C. and the product is isolated by filtration, washed with water and dried at about 60° C. in vacuo. 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide is obtained in this manner, yield: 99.2% by weight, Modification A.

Provenance & Evidence