Ethyl 2-acetylamino-4-thiazoleacetate → (2-Acetylamino-thiazol-4-yl)-acetic acid

HRID 1582960Notes

Reaction equation

HRID 1582960 reaction equation
[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][C:11]([O:13]CC)=[O:12])[N:9]=1)(=[O:3])[CH3:2]>C(O)C>[C:1]([NH:4][C:5]1[S:6][CH:7]=[C:8]([CH2:10][C:11]([OH:13])=[O:12])[N:9]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 3477732Ethyl 2-acetylamino-4-thiazoleacetate

Product 1

HCID 1133014(2-Acetylamino-thiazol-4-yl)-acetic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-(2-acetylaminothiazol-4-yl)acetate was reacted in a mixture of ethanol-1M sodium hydroxide aqueous solution (1:1) at room temperature, and then the reaction mixture was worked up and purified in a usual manner to obtain 2-(2-acetylaminothiazol-4-yl)acetic acid as a colorless solid. MS: 201.

Workup

  1. custompurified in a usual manner

Sources & evidence

ORD record
ord-49663138debb4d7c9d00c3170893b89c
Source dataset
uspto-grants-2004_05
Patent number
US06740662B1

Reaction notes

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