Cesium carbonate → Ethyl 1-(benzyloxycarbonylmethyl)isonipecotate

HRID 1582961노트

반응식

HRID 1582961 반응식
[NH:1]1[CH2:11][CH2:10][CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:3][CH2:2]1.Br[CH2:13][C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15].C(=O)([O-])[O-].[Cs+].[Cs+]>C(#N)C>[CH2:17]([O:16][C:14]([CH2:13][N:1]1[CH2:2][CH2:3][CH:4]([C:5]([O:7][CH2:8][CH3:9])=[O:6])[CH2:10][CH2:11]1)=[O:15])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 62576Benzyl bromoacetateHCID 70770Ethyl 4-piperidinecarboxylate

생성물 1

HCID 22716663Ethyl 1-(benzyloxycarbonylmethyl)isonipecotate

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Ethyl isonipecotate was reacted with benzyl bromoacetate in acetonitrile in the presence of cesium carbonate, and then the reaction mixture was worked up and purified in a usual manner to obtain ethyl 1-(benzyloxycarbonylmethyl)isonipecotate as a colorless oily substance. MS: 306.

후처리

  1. custompurified in a usual manner

출처 및 근거

ORD 기록
ord-d9581f91a3bd4a9abf19569900b05667
출처 데이터셋
uspto-grants-2004_05
특허 번호
US06740662B1

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