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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1582961Generated: October 26, 2026

Cesium carbonate → Ethyl 1-(benzyloxycarbonylmethyl)isonipecotate

https://huagongshe.com/reaction/1582961

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCesium carbonateHCID 10796—
ReactantBenzyl bromoacetateHCID 62576—
ReactantEthyl 4-piperidinecarboxylateHCID 70770—
SolventAcetonitrileHCID 6342—
ProductEthyl 1-(benzyloxycarbonylmethyl)isonipecotateHCID 22716663—

Reaction Steps

Ethyl isonipecotate was reacted with benzyl bromoacetate in acetonitrile in the presence of cesium carbonate, and then the reaction mixture was worked up and purified in a usual manner to obtain ethyl 1-(benzyloxycarbonylmethyl)isonipecotate as a colorless oily substance. MS: 306.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06740662B1
Source datasetuspto-grants-2004_05
ORD IDord-d9581f91a3bd4a9abf19569900b05667
Source noteuspto-grants-2004_05