反应详情

温度

0 °C

To a diethyl ether suspension of magnesium was added dropwise 2-bromothiophene at room temperature, and the whole was reacted. After cooling to 0° C., the reaction mixture was added with 2-chloro-6-methylnicotinic acid and, after being warmed to room temperature, the whole was stirred for 12 hours. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain 2-chloro-6-methyl-3-(thiophene-2-carbonyl)pyridine. NMR1: 7.79 (1H, dd, J=5.0, 1.1 Hz), 7.78 (1H, d, J=7.7 Hz), 2.63 (3H, s).

1. customthe whole was reacted
2. temperatureafter being warmed to room temperature
3. custompurified in a usual manner