反应详情

温度

60 °C

To an acetone solution of 3-(3-chlorobenzoyl)-6-dimethoxymethyl-2-ethylaminopyridine was added 6M hydrochloric acid, and the whole was reacted at room temperature for 5 hours. After removal of the solvent by evaporation, propylene oxide and chloroacetyl chloride were added to the product obtained by a usual liquid-separation treatment in methyl t-butyl ether, and the whole was stirred at 60° C. for 14 hours. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain 2-chloro-N-[3-(3-chlorobenzoyl)-6-formylpyridin-2-yl]-N-ethylacetamide as a yellow oily substance. NMR1: 10.1 (1H, d, J=0.6 Hz), 7.95 (2H, brs), 1.0-1.5 (3H, m).

1. customthe whole was reacted at room temperature for 5 hours
2. customAfter removal of the solvent
3. customby evaporation, propylene oxide and chloroacetyl chloride
4. additionwere added to the product
5. customobtained by a usual liquid-separation treatment in methyl t-butyl ether
6. custompurified in a usual manner