反应详情

A 1.40 g portion of methyl 2-[4-(3-chlorophenyl)-1-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]benzoate was stirred in 20 ml of methanol and 10 ml of a 1M sodium hydroxide aqueous solution at 60° C. for 15 hours. The reaction mixture was cooled to room temperature and 10 ml of 1M hydrochloric acid was added thereto. The resulting precipitates were collected by filtration and recrystallized from ethyl acetate-diisopropyl ether to obtain 540 mg of 2-[4-(3-chlorophenyl)-l-ethyl-7-methyl-2-oxo-1,2-dihydro-1,8-naphthyridin-3-yl]benzoic acid 0.6 hydrate as a colorless crystalline solid.

1. customThe resulting precipitates
2. filtrationwere collected by filtration
3. customrecrystallized from ethyl acetate-diisopropyl ether