2-(Benzyloxy)-5-formylbenzoic acid → 2-(4-Trifluoromethylbenzyloxy)-5-formylbenzoic acid

HRID 1583036Notes

Reaction equation

HRID 1583036 reaction equation
[F:1][C:2]([F:34])([F:33])[C:3]1[CH:32]=[CH:31][C:6]([CH2:7][O:8][C:9]2[CH:28]=[CH:27][C:26]([CH:29]=[O:30])=[CH:25][C:10]=2[C:11]([O:13]CC2C=CC(C(F)(F)F)=CC=2)=[O:12])=[CH:5][CH:4]=1.C(OC1C=CC(C=O)=CC=1C(O)=O)C1C=CC=CC=1>>[F:1][C:2]([F:33])([F:34])[C:3]1[CH:32]=[CH:31][C:6]([CH2:7][O:8][C:9]2[CH:28]=[CH:27][C:26]([CH:29]=[O:30])=[CH:25][C:10]=2[C:11]([OH:13])=[O:12])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 9698702-(Benzyloxy)-5-formylbenzoic acidHCID 227168124-Trifluoromethylbenzyl 2-(4-trifluoromethylbenzyloxy)-5-formylbenzoate

Product 1

HCID 227167872-(4-Trifluoromethylbenzyloxy)-5-formylbenzoic acid

Procedure

2-(4-Trifluoromethylbenzyloxy)-5-formylbenzoic acid was prepared from 4-trifluoromethylbenzyl 2-(4-trifluoromethylbenzyloxy)-5-formylbenzoate (1.41 g, 1 eq) using the same procedure as for 2-benzyloxy-5-formylbenzoic acid. The product was obtained as a white powder (764 mg, 67%). 1H NMR (CDCl3) δ9.97 (s, 1H, O═C—H), 5.41 (s, 2H, CH2Ar).

Sources & evidence

ORD record
ord-535e9d2ab8d943a9bae3511824424b13
Source dataset
uspto-grants-2004_05
Patent number
US06740670B2

Reaction notes

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