HCID 69213104, compound → HCID 86589928, compound

HRID 1583069Notes

Reaction equation

HRID 1583069 reaction equation
[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11]CC2C=CC=CC=2)=[C:7]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]=1[F:23])(=[O:3])[CH3:2]>[Pd].C(OCC)(=O)C>[C:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([C:19]([CH3:22])([CH3:21])[CH3:20])[C:6]=1[F:23])(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 69213104HCID 69213104, compound2×

Product 1

HCID 86589928HCID 86589928, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

Following General Procedure G and using tert-butyl-4-benzyloxy-2-fluoro-phenyl acetate (Compound 13, 2.2 g, 6.96 mmol), ethyl acetate (15 mL) and 5% palladium on carbon (0.436 g) the title compound was obtained as a white solid (1.5 g, 95%).

Sources & evidence

ORD record
ord-8765a733700b4a6db961ae5fa1f9059b
Source dataset
uspto-grants-2004_05
Patent number
US06740676B2

Reaction notes

Loading…