HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Phenylenediacetic acid → (s)-1-[[4-[2-[(s)-2-Benzyloxycarbonyl-pyrrolidin-1-yl]-2-oxo-ethyl]-phenyl]-acetyl]-pyrrolidine-2-carboxylic acid benzyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Phenylenediacetic acid | HCID 81760 | — |
| Reactant | Proline benzyl ester hydrochloride | HCID 2733413 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (s)-1-[[4-[2-[(s)-2-Benzyloxycarbonyl-pyrrolidin-1-yl]-2-oxo-ethyl]-phenyl]-acetyl]-pyrrolidine-2-carboxylic acid benzyl ester | HCID 53878409 | 91.8% |
Reaction Steps
Using General Procedure A with 1.0 g (4.1 mmol) L-Proline benzyl ester hydrochloride and 400 mg (2.1 mmol) 1,4-phenylenediacetic acid afforded, after flash chromatography (EtOAc), 1.07 g (91%) of the title compound as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06740760B2 |
| Source dataset | uspto-grants-2004_05 |
| ORD ID | ord-202bf8be12074530b19e08f3ad9f9912 |
| Source note | uspto-grants-2004_05 |