huagongshe.com
HRID1583181

反应详情

EQUATION

反应方程式

HRID 1583181 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)Cc1ccc(CC(=O)O)cc1
HCID81760

p-Phenylenediacetic acid

C10H10O4

结构：Cl.O=C(OCc1ccccc1)[C@@H]1CCCN1
HCID2733413

Benzyl L-prolinate hydrochloride

C12H16ClNO2

PRODUCTS

生成物

1
结构：O=C(OCc1ccccc1)[C@@H]1CCCN1C(=O)Cc1ccc(CC(=O)N2CCC[C@H]2C(=O)OCc2ccccc2)cc1
HCID53878409

未命名化合物

收率 91.8%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Using General Procedure A with 1.0 g (4.1 mmol) L-Proline benzyl ester hydrochloride and 400 mg (2.1 mmol) 1,4-phenylenediacetic acid afforded, after flash chromatography (EtOAc), 1.07 g (91%) of the title compound as a colorless oil.

WORKUP

后处理

  1. customafforded