HRID1583190

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID702

Ethanol

C2H6O

HCID5351896

trans-β-Hydromuconic acid

C6H8O4

HCID6931635

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)[C@H]1CCCN1C(=O)C/C=C/CC(=O)N1CCC[C@@H]1C(=O)OC(C)(C)C

HCID69895037

未命名化合物

收率 77%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

Using General Procedure A with 1.5 g (8.76 mmol) D-Proline tert-butyl ester and 630 mg (4.37 mmol) trans-3-hexenedioic acid afforded, after flash chromatography (10% EtOH in EtOAc), 1.59 g (77%) of the title compound as a white crystalline solid. MS m/e (%): 568 (M+NH4+, 35), 451 (M+H+, 100), 395 ([M+H—C3H8]+, 32), 339 (M+H—2C3H8]+, 40).

WORKUP

后处理

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