Diethyl Ether → HCID 131714402, compound

HRID 1583240Notes

Reaction equation

HRID 1583240 reaction equation
CC(C)(OC([NH:7][CH:8]1[CH2:11][N:10]([C:12](=[O:20])[CH:13]=[CH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:9]1=[O:21])=O)C.CCOCC.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[NH2:7][CH:8]1[CH2:11][N:10]([C:12](=[O:20])[CH:13]=[CH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])[C:9]1=[O:21]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 6422Trifluoroacetic acidHCID 131714404HCID 131714404, compound

Product 1

HCID 131714402HCID 131714402, compound

Conditions

Temperature
0 °C

Procedure

[1(E); 3S]-4-[3-[[(1,1-Dimethylethoxy)-carbonyl]amino]-2-oxo-1-azetidinyl]-4-oxo-2-butenoic acid, ethyl ester (2 g) was dissolved in 15 ml of trifluoroacetic acid and stirred for 15 minutes at 0° C. After adding ether, the title compound crystallized quantitatively from the solution as white crystals, melting point 138° C. (dec.).

Workup

  1. customthe title compound crystallized quantitatively from the solution as white crystals, melting point 138° C. (dec.)

Sources & evidence

ORD record
ord-5f319ca01b41460e9805dc44bf248e07
Source dataset
uspto-grants-1985_11
Patent number
US04551277

Reaction notes

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