5-Aminosalicylic Acid → HCID 20260259, compound

HRID 1583252Notes

Reaction equation

HRID 1583252 reaction equation
[C:1](Cl)(=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[NH2:11][C:12]1[CH:20]=[C:16]([C:17]([OH:19])=[O:18])[C:15]([OH:21])=[CH:14][CH:13]=1>C(N(CC)CC)C>[OH:21][C:15]1[CH:14]=[CH:13][C:12]([NH:11][C:1](=[O:9])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[CH:20][C:16]=1[C:17]([OH:19])=[O:18]

Participants

4

Reactant 2

HCID 40755-Aminosalicylic AcidHCID 8124Octanoyl chloride

Product 1

HCID 20260259HCID 20260259, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In the manner of Example 57 were reacted 3.4 ml of octanoyl chloride, 3.0 g of 5-amino salicylic acid and 2.8 ml of triethylamine. Recrystallization from methanol gave the title compound--m.p. ca. 200°-204° C.

Workup

  1. customRecrystallization from methanol

Sources & evidence

ORD record
ord-f2a37e22d2564e56b403cf91d9f107fc
Source dataset
uspto-grants-1985_11
Patent number
US04551279

Reaction notes

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