Diethyl Ether → 75863-26-2

HRID 1583258Notes

Reaction equation

HRID 1583258 reaction equation
[N+](C(S(C1C=CC(C)=CC=1)(=O)=O)([C:5]1[C@:22]2(C)[C@H:8]([C@H:9]3[C@H:19]([CH2:20][CH2:21]2)[C@:17]2([CH3:18])[C:12](=[CH:13][C:14](=[O:24])[CH:15]=[CH:16]2)[CH2:11][CH2:10]3)[CH2:7][CH:6]=1)C)#[C-].C([O:37][CH2:38][CH3:39])C.[CH2:40](Cl)Cl>>[CH3:40][C:38](=[O:37])[C:39]1[C@:22]2([CH3:5])[C@H:8]([C@H:9]3[C@H:19]([CH2:20][CH2:21]2)[C@:17]2([CH3:18])[C:12](=[CH:13][C:14](=[O:24])[CH:15]=[CH:16]2)[CH2:11][CH2:10]3)[CH2:7][CH:6]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 18600037HCID 18600037, compound

Product 1

HCID 22284775863-26-2

Procedure

The compound prepared in Example 9a (450 mg) was hydrolized in methylenechloride (15 ml) and diethylether (30 ml) at 20° C. for two minutes. The product obtained was purified by filtration over alumina. Yield 235 mg (75%). Crystallization from methanol gave the title product, m.p. 200°-204° C. (dec.) (alpha)22 +134 (CHCl3, c 1.00).

Workup

  1. customThe product obtained
  2. filtrationwas purified by filtration over alumina
  3. customCrystallization from methanol

Sources & evidence

ORD record
ord-6bc7793d659d4fc882945421b7432e9c
Source dataset
uspto-grants-1985_11
Patent number
US04551278

Reaction notes

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