Sulfuric Acid → 4-(2-Bromo-1,1,2-trifluoroethoxy)phenol

HRID 1583284Notes

Reaction equation

HRID 1583284 reaction equation
[Br:1][CH:2]([F:14])[C:3]([F:13])([F:12])[O:4][C:5]1[CH:11]=[CH:10][C:8](N)=[CH:7][CH:6]=1.S(=O)(=O)(O)[OH:16].N([O-])=O.[Na+]>O>[Br:1][CH:2]([F:14])[C:3]([F:13])([F:12])[O:4][C:5]1[CH:11]=[CH:10][C:8]([OH:16])=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 132284964-(2-Bromo-1,1,2-trifluoroethoxy)anilineHCID 23668193Sodium Nitrite

Product 1

HCID 132284984-(2-Bromo-1,1,2-trifluoroethoxy)phenol

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
10 °C

Procedure

40 g of 4-(2-bromo-1,1,2-trifluoroethoxy)-aniline were added dropwise, at 10° C., to 400 ml of 2.5N sulfuric acid, after which 11 g of sodium nitrite in 30 ml of water were added dropwise at 0° C., and the mixture was stirred for a further hour at 10° C.

Sources & evidence

ORD record
ord-99cf52be4efc4b3d958bacf9e1751912
Source dataset
uspto-grants-1985_11
Patent number
US04551448

Reaction notes

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