HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1583284Generated: November 2, 2026
Sulfuric Acid → 4-(2-Bromo-1,1,2-trifluoroethoxy)phenol
https://huagongshe.com/reaction/1583284
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 4-(2-Bromo-1,1,2-trifluoroethoxy)aniline | HCID 13228496 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-Bromo-1,1,2-trifluoroethoxy)phenol | HCID 13228498 | — |
Reaction Steps
40 g of 4-(2-bromo-1,1,2-trifluoroethoxy)-aniline were added dropwise, at 10° C., to 400 ml of 2.5N sulfuric acid, after which 11 g of sodium nitrite in 30 ml of water were added dropwise at 0° C., and the mixture was stirred for a further hour at 10° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04551448 |
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| Source dataset | uspto-grants-1985_11 |
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| ORD ID | ord-99cf52be4efc4b3d958bacf9e1751912 |
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| Source note | uspto-grants-1985_11 |
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