Bromine → 2-Bromo-4-(2-bromo-1,1,2-trifluoroethoxy)phenol
Reaction equation
[Br:1]Br.[Br:3][CH:4]([F:16])[C:5]([F:15])([F:14])[O:6][C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[CH:9][CH:8]=1>C(Cl)(Cl)Cl>[Br:1][C:9]1[CH:8]=[C:7]([O:6][C:5]([F:14])([F:15])[CH:4]([Br:3])[F:16])[CH:12]=[CH:11][C:10]=1[OH:13]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
7.2 g of bromine in 30 ml of chloroform were added dropwise, at 25° C., to a solution of 12.2 g of 4-(2-bromo-1,1,2-trifluoroethoxy)-phenol in 100 ml of anhydrous chloroform, and the mixture was stirred for 12 hours at 25° C. The solvent was removed, and the residue was distilled at 100° C./0.4 mbar to give 15.5 g of pure product.
Workup
- customThe solvent was removed
- distillationthe residue was distilled at 100° C./0.4 mbar
Sources & evidence
- ORD record
- ord-1638de6bea5d461c9d22e044ccf22654
- Source dataset
- uspto-grants-1985_11
- Patent number
- US04551448
Reaction notes
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