反应详情

To a mixture of 6.8 g of 3-(n-butyl)-4-(2-hydroxyethoxy)-1-phenyl-1,8-naphthyridin-2(1H)one and 150 ml of anhydrous dioxane there is added 0.8 g of sodium hydride (60% oil dispersion) with stirring. The reaction mixture is stirred and warmed on a steam bath for 30 minutes, followed by the dropwise addition of 2.6 g of 95% 2-bromoethanol. The reaction mixture is stirred and refluxed for 24 hours, the solvent is removed in vacuo and the residual solid is dissolved in chloroform. The chloroform solution is successively washed with water, 0.5N sodium hydroxide and water. The organic layer is dried over magnesium sulfate, filtered and concentrated to dryness to yield the product of this example.

1. stirringThe reaction mixture is stirred
2. temperaturewarmed on a steam bath for 30 minutes
3. stirringThe reaction mixture is stirred
4. temperaturerefluxed for 24 hours
5. customthe solvent is removed in vacuo
6. dissolutionthe residual solid is dissolved in chloroform
7. washThe chloroform solution is successively washed with water, 0.5N sodium hydroxide and water
8. dry with materialThe organic layer is dried over magnesium sulfate
9. filtrationfiltered
10. concentrationconcentrated to dryness
11. customto yield the product of this example