HCID 54197380, compound → HCID 23316677, compound

HRID 1583331Notes

Reaction equation

HRID 1583331 reaction equation
C([O:8][C:9]([CH:11]1[C:18](=[O:19])[N:17]2[CH:13]([CH2:14][CH2:15][C:16]2=[O:20])[CH2:12]1)=[O:10])C1C=CC=CC=1.[H][H]>O1CCOCC1.[Pd]>[O:19]=[C:18]1[N:17]2[CH:13]([CH2:14][CH2:15][C:16]2=[O:20])[CH2:12][CH:11]1[C:9]([OH:10])=[O:8]

Participants

5

Reactant 2

HCID 54197380HCID 54197380, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23316677HCID 23316677, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 312751,4-DioxaneSolvent

Procedure

A solution of hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid benzyl ester 25.90.1 g, yy mole) in dioxane (200 ml) is treated with hydrogen gas in the presence of 20% Pd/C catalyst for eight hours. The mixture is filtered and concentrated at reduced pressure (below 25° C.) to yield pure hexahydro-3,5-dioxo-1H-pyrrolizine-2-carboxylic acid.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated at reduced pressure (below 25° C.)

Sources & evidence

ORD record
ord-1148e262ad6c441880a3014280eb46da
Source dataset
uspto-grants-1985_11
Patent number
US04551470

Reaction notes

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