Methyl iodide → HCID 13557521, compound

HRID 1583396Notes

Reaction equation

HRID 1583396 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[N:8]=[C:7]1[CH:13]=[CH:14][C:15]([C:17]([NH:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]3[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=3)=[O:18])=[CH:16][N:6]1[C:5]2=[O:30].[I:31][CH3:32]>>[I-:31].[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[CH3:12])[N:8]=[C:7]1[CH:13]=[CH:14][C:15]([C:17]([NH:19][CH2:20][CH2:21][CH2:22][CH2:23][C:24]3[CH:25]=[N+:26]([CH3:32])[CH:27]=[CH:28][CH:29]=3)=[O:18])=[CH:16][N:6]1[C:5]2=[O:30]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 13557496HCID 13557496, compound

Product 1

HCID 13557521HCID 13557521, compoundYield 77.2%

Procedure

A mixture of 2.2 g of 2,3-dimethyl-11-oxo-N-[4-(3-pyridinyl)butyl]-11H-pyrido[2,1-b]quinazoline-8-carboxamide and 10 ml of iodomethane was stirred at room temperature, under argon form 3 days. An orange gum was obtained after removal of the excess iodomethane which was crystallized from methanol to yield 2.3 g (77.2%) of orange crystals, m.p. 129° dec.

Workup

  1. customform 3 days
  2. customAn orange gum was obtained
  3. customafter removal of the excess iodomethane which
  4. customwas crystallized from methanol

Sources & evidence

ORD record
ord-4fdf5063bc0748658bb5247a86d3aefe
Source dataset
uspto-grants-1985_11
Patent number
US04551460

Reaction notes

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