HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(5-Pyrimidinyl)-3-butyn-1-ol → 4-(Pyrimidin-5-yl)butan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(5-Pyrimidinyl)-3-butyn-1-ol | HCID 12181448 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 4-(Pyrimidin-5-yl)butan-1-ol | HCID 13557542 | 80% |
Reaction Steps
A solution of 18.5 g of 4-(5-pyrimidinyl)-3-butyn-1-ol in 300 ml of isopropanol was hydrogenated over a total of 3.5 g of 10% palladium on carbon added in three portions. Evaporation of the solvent and distillation of the residue gave 15.2 g (80%) of 5-pyrimidinebutanol, bp 175°-180° C./0.5 mm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04551460 |
| Source dataset | uspto-grants-1985_11 |
| ORD ID | ord-2c90ddd3170f4446bfc5186e8a800e6b |
| Source note | uspto-grants-1985_11 |