HCID 12181448, compound → 4-(Pyrimidin-5-yl)butan-1-ol

HRID 1583411Notes

Reaction equation

HRID 1583411 reaction equation
[N:1]1[CH:6]=[C:5]([C:7]#[C:8][CH2:9][CH2:10][OH:11])[CH:4]=[N:3][CH:2]=1>C(O)(C)C.[Pd]>[N:1]1[CH:6]=[C:5]([CH2:7][CH2:8][CH2:9][CH2:10][OH:11])[CH:4]=[N:3][CH:2]=1

Participants

4

Reactant 1

HCID 12181448HCID 12181448, compound

Product 1

HCID 135575424-(Pyrimidin-5-yl)butan-1-olYield 80%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3776IsopropanolSolvent

Procedure

A solution of 18.5 g of 4-(5-pyrimidinyl)-3-butyn-1-ol in 300 ml of isopropanol was hydrogenated over a total of 3.5 g of 10% palladium on carbon added in three portions. Evaporation of the solvent and distillation of the residue gave 15.2 g (80%) of 5-pyrimidinebutanol, bp 175°-180° C./0.5 mm.

Workup

  1. additionadded in three portions
  2. customEvaporation of the solvent and distillation of the residue

Sources & evidence

ORD record
ord-2c90ddd3170f4446bfc5186e8a800e6b
Source dataset
uspto-grants-1985_11
Patent number
US04551460

Reaction notes

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