反应详情

A solution of 23.2 g of 2-[6-(5-pyrimidinyl)hexyl]-1H-isoindole-1,3-(2H)-dione and 14.6 ml of hydrazine hydrate in 320 ml of ethanol was heated to reflux for 3 hours. The cooled mixture was filtered and the filtrate was concentrated and dissolved in dichloromethne. The solution was washed with 5% sodium hydroxide, dried and evaporated to an oil which was evaportively distilled to yield 12.0 g (90%) of 5-pyrimidinehexanamine, bp 120°-128° C./0.6 mm.

1. temperatureto reflux for 3 hours
2. filtrationThe cooled mixture was filtered
3. concentrationthe filtrate was concentrated
4. dissolutiondissolved in dichloromethne
5. washThe solution was washed with 5% sodium hydroxide
6. customdried
7. customevaporated to an oil which
8. distillationwas evaportively distilled