Pyridine → HCID 20260616, compound

HRID 1583423Notes

Reaction equation

HRID 1583423 reaction equation
[BrH:1].[Br:2][CH2:3][CH2:4][CH2:5][NH2:6].[N:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(O)C>[BrH:2].[Br-:1].[NH2:6][CH2:5][CH2:4][CH2:3][N+:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 1049PyridineHCID 787013-Bromopropylamine hydrobromide

Product 1

HCID 20260616HCID 20260616, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 16.5 g of 3-bromopropanamine hydrobromide and 6.0 ml (5.9 g) of pyridine in 75 ml of ethanol was heated under reflux for 18 hours. The cooled reaction was filtered and the solid was washed with ethanol to give 17.0 g (76%) of 1-(3-aminopropyl)pyridinium bromide hydrobromide as colorless crystals, mp 178°-179°. The analytical sample was obtained by recrystallization from methanol and had mp. 176°-179° C.

Workup

  1. temperatureunder reflux for 18 hours
  2. customThe cooled reaction
  3. filtrationwas filtered
  4. washthe solid was washed with ethanol

Sources & evidence

ORD record
ord-41d4d1890120428683089700685f3afd
Source dataset
uspto-grants-1985_11
Patent number
US04551460

Reaction notes

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