18-Crown-6 → HCID 13557263, compound

Participants

Reaction Steps

This compound was prepared in the manner of Example 1, Step C; using 1.3 grams (0.01 mole) of 5,6-dihydro-4,4-dimethyl-2H-1,2-oxazin-3(4H)-one, 3.1 grams (0.01 mole) of 2-chloro-4-[(N-methoxy-N-methylamino)carbonylamino]phenylmethyl bromide, 1.4 grams (0.01 mole) of potassium bromide and 0.1 gram (0.0004 mole) of 1,4,7,10,13,16-hexaoxacyclooctadecane in 50 ml of acetonitrile. The yield of 2-(2-chloro-4-[(N-methoxy-N-methylamino)carbonylamino]phenyl)methyl-5,6-dihydro-4,4-dimethyl-1H-1,2,-oxazin-3(4H)-one was 2.9 grams; m.p. 116°-118° C.

Provenance & Evidence