18-Crown-6 → HCID 13557263、化合物

HRID 1583487ノート

反応式

HRID 1583487 の反応式
[CH3:1][C:2]1([CH3:9])[CH2:7][CH2:6][O:5][NH:4][C:3]1=[O:8].[Cl:10][C:11]1[CH:16]=[C:15]([NH:17][C:18]([N:20]([O:22][CH3:23])[CH3:21])=[O:19])[CH:14]=[CH:13][C:12]=1[CH2:24]Br.[Br-].[K+].O1CCOCCOCCOCCOCCOCC1.O1C=CCC(=O)N1>C(#N)C>[Cl:10][C:11]1[CH:16]=[C:15]([NH:17][C:18]([N:20]([O:22][CH3:23])[CH3:21])=[O:19])[CH:14]=[CH:13][C:12]=1[CH2:24][N:4]1[C:3](=[O:8])[C:2]([CH3:9])([CH3:1])[CH2:7][CH2:6][O:5]1

参加物

7

反応物 5

HCID 2855718-Crown-6HCID 253877Potassium BromideHCID 13557273HCID 13557273、化合物HCID 13557277HCID 13557277、化合物HCID 21873527Oxazinone

生成物 1

HCID 13557263HCID 13557263、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

This compound was prepared in the manner of Example 1, Step C; using 1.3 grams (0.01 mole) of 5,6-dihydro-4,4-dimethyl-2H-1,2-oxazin-3(4H)-one, 3.1 grams (0.01 mole) of 2-chloro-4-[(N-methoxy-N-methylamino)carbonylamino]phenylmethyl bromide, 1.4 grams (0.01 mole) of potassium bromide and 0.1 gram (0.0004 mole) of 1,4,7,10,13,16-hexaoxacyclooctadecane in 50 ml of acetonitrile. The yield of 2-(2-chloro-4-[(N-methoxy-N-methylamino)carbonylamino]phenyl)methyl-5,6-dihydro-4,4-dimethyl-1H-1,2,-oxazin-3(4H)-one was 2.9 grams; m.p. 116°-118° C.

後処理

  1. customThis compound was prepared in the manner of Example 1, Step C

出典と根拠

ORDレコード
ord-b9d674cfcba04477adfa1d8a852f20f5
出典データセット
uspto-grants-1985_11
特許番号
US04552585

反応ノート

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