反应详情

To 3.1 g. of N-(1-methylhexyl)-[(3-pyridyl)methyl]amine dissolved in approximately 20 ml. of ethanol-free chloroform was added 1.8 g. of 2-chloroethylisothiocyanate followed by 2.08 ml. of triethylamine. The reaction mixture was stirred at room temperature overnight and then refluxed for approximately 4 hours. The solvent was evaporated under reduced pressure and the residue was chromatographed over silica gel while eluting with chloroform/acetone to afford approximately 4.0 g. of the desired product. Yield 91%.

1. temperaturerefluxed for approximately 4 hours
2. customThe solvent was evaporated under reduced pressure
3. customthe residue was chromatographed over silica gel
4. washwhile eluting with chloroform/acetone
5. customto afford approximately 4.0 g