Sodium Hydroxide → beta-(3,4-Diethoxyphenyl)-alpha-mercaptoacrylic acid

HRID 1583576Notes

Reaction equation

HRID 1583576 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:15]=[CH:16][C:17]=1[O:18][CH2:19][CH3:20])[CH:7]=[C:8]1[S:12]C(=S)N[C:9]1=[O:14])[CH3:2].[OH-:21].[Na+]>O>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:7]=[C:8]([SH:12])[C:9]([OH:21])=[O:14])[CH:15]=[CH:16][C:17]=1[O:18][CH2:19][CH3:20])[CH3:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 31088255-(3,4-Diethoxybenzylidene)rhodanine

Product 1

HCID 86131838beta-(3,4-Diethoxyphenyl)-alpha-mercaptoacrylic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 33.0 g. of 5-(3,4-diethoxybenzylidene)rhodanine and 23.4 g. of sodium hydroxide in 148 ml. of water was heated to 70° C. for 30 minutes. The solution was cooled and filtered and the filtrate was acidified by pouring into excess cold 10% hydrochloric acid. The precipitate was collected by filtration affording 25 g. of the desired subtitle intermediate which was used without further purification.

Workup

  1. temperatureThe solution was cooled
  2. filtrationfiltered
  3. additionby pouring into excess cold 10% hydrochloric acid
  4. filtrationThe precipitate was collected by filtration
  5. customaffording 25 g
  6. customof the desired subtitle intermediate which was used without further purification

Sources & evidence

ORD record
ord-a06d9df7b111478599ef633c01e2a943
Source dataset
uspto-grants-1985_11
Patent number
US04552891

Reaction notes

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