反应详情

Stannous chloride dihydrate (5.7 g) was added to a solution of 1.8 g of 5-morpholino-6-fluoro-8-nitroquinaldine in 30 ml of acetic acid and 20 ml of concentrated hydrochloric acid was added dropwise to the mixture with stirring. After completion of addition the mixture was stirred at room temperature for 1 hour, diluted with water and rendered alkaline with an aqueous sodium hydroxide solution to form precipitations, which then were extracted with dichloromethane, after drying over magnesium sulfate the solvent was distilled off to give 1.30 g of 5-morpholino-6-fluoro-8-aminoquinaldine.

1. additionwas added dropwise to the mixture
2. additionAfter completion of addition the mixture
3. stirringwas stirred at room temperature for 1 hour
4. customto form
5. customprecipitations, which
6. extractionthen were extracted with dichloromethane
7. dry with materialafter drying over magnesium sulfate the solvent
8. distillationwas distilled off