Hydrochloric Acid → HCID 70489399, compound

HRID 1583621Notes

Reaction equation

HRID 1583621 reaction equation
[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([OH:18])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:19])[CH2:6][CH2:5][C:4]=3[C:3]=1[N:20]1[CH2:25][CH2:24][CH:23]([NH:26]C(=O)C)[CH2:22][CH2:21]1.[OH-].[Na+].[ClH:32]>>[ClH:32].[F:1][C:2]1[CH:14]=[C:12]2[C:13]3[N:8]([CH:9]=[C:10]([C:16]([OH:18])=[O:17])[C:11]2=[O:15])[CH:7]([CH3:19])[CH2:6][CH2:5][C:4]=3[C:3]=1[N:20]1[CH2:21][CH2:22][CH:23]([NH2:26])[CH2:24][CH2:25]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13044297HCID 13044297, compound

Product 1

HCID 70489399HCID 70489399, compound

Procedure

A mixture of 2 g of 9-fluoro-8-(4-acetylamino-1-piperidyl)-5-methyl-6,7dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid and 50 ml of a 10% aqueous sodium hydroxide solution was heated for 10 hours. After completion of reaction, the reaction mixture was cooled and adjusted to pH 4 with dilute hydrochloric acid (10%) to form precipitations, which then were recrystallized from ethanol-water to give 0.7 g of 9-fluoro-8-(4-amino-1-piperidyl)-5-methyl-6,7-dihydro-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid hydrochloride. m.p. not lower than 300° C., white rhombic crystals.

Workup

  1. temperaturewas heated for 10 hours
  2. customAfter completion of reaction
  3. temperaturethe reaction mixture was cooled
  4. customto form
  5. customprecipitations, which
  6. customthen were recrystallized from ethanol-water

Sources & evidence

ORD record
ord-07b22463fb7c4e9fa2634add1c3a2e77
Source dataset
uspto-grants-1985_11
Patent number
US04552879

Reaction notes

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