Formaldehyde → 2-(Hydroxymethyl)-3-methoxy-2-methylpropanal

HRID 1583658Notes

Reaction equation

HRID 1583658 reaction equation
C(N(CC)CC)C.[CH2:8]=[O:9].[O:10]=[CH:11][C:12](=[CH2:14])[CH3:13].[CH3:15][OH:16]>>[CH3:8][O:9][CH2:13][C:12]([CH2:11][OH:10])([CH3:14])[CH:15]=[O:16]

Participants

5

Reactant 4

HCID 712FormaldehydeHCID 887MethanolHCID 6562MethacroleinHCID 8471Triethylamine

Product 1

HCID 30203092-(Hydroxymethyl)-3-methoxy-2-methylpropanalYield 78%

Procedure

22 g of triethylamine are added to a mixture of 590 g of methanol, 330 g of 30% strength formaldehyde solution and 210 g of methacrolein in the course of 10 minutes, and the solution is kept at the boiling point for 8 hours. The low-boiling components are separated off, after which 312 g (=78% yield, based on methacrolein) of the title compound of boiling point 120°-125° C./24 mbar are isolated by distillation under reduced pressure.

Workup

  1. customThe low-boiling components are separated off

Sources & evidence

ORD record
ord-71ca3afbd0054e71bacb155d06f18a70
Source dataset
uspto-grants-1985_11
Patent number
US04552985

Reaction notes

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