Phosgene → HCID 13535829, compound

HRID 1583753Notes

Reaction equation

HRID 1583753 reaction equation
[CH3:1][CH:2]1[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([NH:11][NH:12][C:13]([N:15]([O:17][CH3:18])[CH3:16])=[O:14])[C:4]=2[O:3]1.[C:19](Cl)([Cl:21])=[O:20]>C1C=CC=CC=1>[Cl:21][C:19]([N:11]([C:10]1[C:4]2[O:3][CH:2]([CH3:1])[CH2:6][C:5]=2[CH:7]=[CH:8][CH:9]=1)[NH:12][C:13]([N:15]([O:17][CH3:18])[CH3:16])=[O:14])=[O:20]

Participants

4

Reactant 2

HCID 6371PhosgeneHCID 135358281-(2,3-Dihydro-2-methylbenzofuran-7-yl)-4-methoxy-4-methylsemicarbazide

Product 1

HCID 13535829HCID 13535829, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

3.0 g of 1E was added to a stirred solution of 75 ml of 12.5% phosgene in benzene. The resulting mixture was stirred for 2 hours at room temperature, then the solvent was evaporated to give 1-(chlorocarbonyl)-1-(2,3-dihydro-2-methylbenzofuran-7-yl)-4-methoxy-4-methylsemicarbazide (1F), as an amber syrup.

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-4d8dff9d476a411a80d54c86637d488e
Source dataset
uspto-grants-1985_11
Patent number
US04554283

Reaction notes

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