反应详情

A stirred mixture of 4.7 g (0.013 mole) of 5-decoxy-6-methoxy-8-nitroquinoline, 12 g of degreased 40 mesh iron filings, 6 ml of butyl ether, 6 ml of acetic acid and 30 ml of water was heated at 100° for 2 hr, cooled and filtered. The solid was washed with water, dried and extracted with diethyl ether. Evaporation of the diethyl ether, solution of the residue in petroleum ether (20°-40°) and cooling in Dry-Ice acetone gave 3.6 g of pale green solid. Two crystallizations from petroleum ether (20°-40°) (carbon) provided 2.3 g (54%) of amino compound as yellow-green solid, mp 65°.

1. temperaturewas heated at 100° for 2 hr
2. temperaturecooled
3. filtrationfiltered
4. washThe solid was washed with water
5. customdried
6. extractionextracted with diethyl ether
7. customEvaporation of the diethyl ether, solution of the residue in petroleum ether (20°-40°)
8. temperaturecooling in Dry-Ice acetone