Hydrochloric Acid → 2-Amino-5-tert-butyl-4-(hexadecyloxy)phenol--hydrogen chloride (1/1)

HRID 1583920Notes

Reaction equation

HRID 1583920 reaction equation
[C:1]([C:5]1[C:14]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])=[CH:13][C:8]2[N:9]=C(C)[O:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:32]>C(O)C>[ClH:32].[NH2:9][C:8]1[CH:13]=[C:14]([O:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31])[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][C:7]=1[OH:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13076757HCID 13076757, compound

Product 1

HCID 130767632-Amino-5-tert-butyl-4-(hexadecyloxy)phenol--hydrogen chloride (1/1)Yield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7.3 g of the benzoxazole compound obtained in Step (d) above was refluxed for 3 hours together with 30 ml of ethanol and 20 ml of concentrated hydrochloric acid. After the completion of the reaction, the reaction mixture was allowed to stand and cool. The crystals thus precipitated were collected by filtration, washed with water and then washed with acetone. Thus, 6.9 g (92% yield) of 2-amino-5-tert-butyl-4-hexadecyloxyphenol hydrochloride was obtained.

Workup

  1. customAfter the completion of the reaction
  2. temperaturecool
  3. customThe crystals thus precipitated
  4. filtrationwere collected by filtration
  5. washwashed with water
  6. washwashed with acetone

Sources & evidence

ORD record
ord-9ae93751bd5944c3a27a1a3af9a0712a
Source dataset
uspto-grants-1985_11
Patent number
US04555470

Reaction notes

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