HCID 20257367, compound → HCID 20257377, compound

HRID 1583939Notes

Reaction equation

HRID 1583939 reaction equation
[CH3:1][C:2]1([CH3:18])[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14])[CH:8]=2)[NH:3]1.[H][H]>[Pd].C(O)C>[CH3:1][C:2]1([CH3:18])[CH2:11][CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:12]([CH3:17])[C:13]([O:15][CH3:16])=[O:14])[CH:8]=2)[NH:3]1

Participants

5

Reactant 2

HCID 20257367HCID 20257367, compound2×HCID 178418361HCID 178418361, compound

Product 1

HCID 20257377HCID 20257377, compoundYield 102.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3 g of methyl 2-(1,2-dihydro-2,2-dimethylquinolin-6-yl)propionate (Compound 7) were added to absolute ethanol. Palladium-on-carbon was further added to the solution, and the mixture was reacted with bubbling hydrogen gas at room temperature for 4 hours with stirring. After the reaction, the catalyst was filtered off and ethanol was distilled off to give 3.1 g of methyl 2-(1,2,3,4-tetrahydro-2,2-dimethylquinolin-6-yl)propionate (Compound 11).

Workup

  1. customAfter the reaction
  2. filtrationthe catalyst was filtered off
  3. distillationethanol was distilled off

Sources & evidence

ORD record
ord-b949b24facde418cbc8507ce55246abc
Source dataset
uspto-grants-1985_11
Patent number
US04555513

Reaction notes

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